Lung-resident SARS-CoV-2 peptide-specific immune responses in perfused 3D human lung explant models.

ABSTRACT:

Introduction

Multi-specific and long-lasting T-cell immunity has been recognized to indicate long-term protection against pathogens, including the novel coronavirus, SARS-CoV-2, which is the causative agent of the COVID-19 pandemic. Functional significance of peripheral memory T cells in individuals recovered from COVID-19 (COVID-19⁺) is beginning to be appreciated; however, the role of lung tissue-resident memory (lung TRM) T cells in SARS-CoV-2 infection is still being investigated. This is, in part, due to the lack of preclinical tissue models available to follow the convalescence period.

Methods

Here, we utilize a perfused three-dimensional (3D) human lung-tissue model and show pre-existing local T-cell immunity against SARS-CoV-2 proteins in lung tissues.

SUBMITTER: Goliwas KF 

PROVIDER: S-EPMC12279861 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature