Notoginsenoside R1 attenuates tendinopathy through inhibiting inflammation and matrix metalloproteinases expression.

ABSTRACT:

Research purpose

The purpose of this study is to demonstrate the effectiveness of Notoginsenoside R1 (NGR1) in treating tendinopathy and to reveal its potential mechanisms.

Materials and methods

This study performed a preliminary network-based assessment of the potential targets that NGR1-associated in the treatment of tendinopathy, which includes PPI network analysis, GO enrichment, KEGG pathway enrichment analysis, and molecular docking. The therapeutic efficacy of NGR1 in vivo was then assessed using a collagenase-induced rat model of tendinopathy. Furthermore, the underlying mechanism was explored through LPS-induced inflammatory responses in tenocytes in vitro.

Results

Network-based assessment indicated that key targets associated with NGR1 in treat

SUBMITTER: Han Q 

PROVIDER: S-EPMC12279872 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature