The impacts of different eyes, individual differences, and different time points in healthy rats on the variability of visual electrophysiological examination indicators.

ABSTRACT:

Purpose

This article discussed the repeatability and coefficient of variation (CV) of flash visual evoked potential (FVEP) and full-field electroretinogram (ffERG) indicators of different eyes, individuals, and time points of normal male Sprague-Dawley rats, providing a reference for selecting a reasonable control scheme for retinal and optic nerve disease rat models.

Methods

Twenty normal 6-8 week Sprague-Dawley rats were selected, from which 10 randomly chosen rats underwent ffERG examination and the other 10 underwent FVEP examination. At different time points (1 d, 7 d), Roland visual electrophysiological device was utilized to record in FVEP P2 peak time and N2-P2 amplitude, peak time and amplitude of dark-adapted 0.01 ERG b-wave, peak time and amplitude of dark-adapted

SUBMITTER: Chen H 

PROVIDER: S-EPMC12279882 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature