Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders.

ABSTRACT: Extant phenotypic and genetic literature has established consistent relationships between autoimmune, autoinflammatory, and psychiatric disorders. However, a comprehensive model investigating the association between a broad range of psychiatric disorders and immune-mediated disease in a multivariate framework is lacking. We utilized Genomic Structural Equation Modeling (Genomic SEM) to establish a factor structure across 11 immune-mediated diseases. Genetic correlations between these immune factors were examined with five established factors across 13 psychiatric disorders. We develop and validate a new heterogeneity metric, Q_Factor, that quantifies the degree to which factor correlations are driven by more specific pairwise associations, which were further investigated in the f

SUBMITTER: Breunig S 

PROVIDER: S-EPMC12279975 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature