PSAT1 inhibits ferroptosis in osteosarcoma cells by activating the Xct/GPX4 signaling axis.

ABSTRACT: Osteosarcoma is a prevalent primary malignant bone tumor predominantly affecting children and adolescents, characterized by a poor survival rate and prognosis. Currently, ferroptosis is a newly defined form of cell death, but the mechanism between it and osteosarcoma is unclear. To further investigate the relationship between osteosarcoma and ferroptosis, it is important to search for new biomolecular factors. We used bioinformatics to dig deeper into the ferroptosis gene PSAT1, which is closely associated with osteosarcoma. Although PSAT1 has been reported in other types of tumours and plays an important role in the development of many tumours, such as melanoma and breast cancer, little research has been done in the field of osteosarcoma. The results indicated that PSAT1 could promote the

SUBMITTER: Wang P 

PROVIDER: S-EPMC12280000 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature