Epidemiological Genomics of Klebsiella pneumoniae isolates from hospitals across Colombia.

ABSTRACT: Klebsiella pneumoniae is one of the most important nosocomial pathogens worldwide. In Colombia, K. pneumoniae has been identified as the second most frequent microbial etiologic agent of healthcare-associated infections. We conducted a prospective local study of 335 K. pneumoniae isolates in 26 nationwide hospitals from 2020 to 2021. We found that the spread of carbapenem resistance was mediated by successful clones belonging to sequence types (ST) such as ST11, ST1082, and ST307, related to intra-hospital infections. We observed that bla_KPC remains the primary resistance mechanism to carbapenems and that, unlike other countries, ST11 strains commonly carry bla_KPC-3. We identified the recent introduction and circulation of new sequence types with different resistance

SUBMITTER: Medina VA 

PROVIDER: S-EPMC12280007 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature