A parametric study of bubble dynamics and lesion formation in liver tissue phantom during pressure-modulated shockwave histotripsy.

ABSTRACT: Pressure-modulated shockwave histotripsy (PSH) is a new type of histotripsy that has recently been proposed for precise mechanical tissue fractionation without inducing the shock scattering effect. Though a previous initial proof-of-concept study clearly demonstrated the feasibility of PSH through introducing the pressure modulation time point (t_m) to minimise the shock scattering effect, this study was limited to the examination of the effect of a single PSH pulse at a constant t_m on bubble dynamics. Here, we investigated the effects of varying PSH exposure conditions, particularly changes of t_m and the number of pulses, on bubble dynamics and lesion formation in liver tissue phantoms. Our experimental results reveal that a gradual increase in t_m

SUBMITTER: Park JH 

PROVIDER: S-EPMC12280012 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature