Early intervention with electrical stimulation reduces neural damage after stroke in non-human primates.

ABSTRACT: For patients experiencing ischemic stroke, acute intervention offers the most critical therapeutic opportunity as it can reduce irreversible tissue injury and improve functional outcomes. However, currently available treatments within the acute window are highly limited and have strict patient selection criteria. Although emerging neuromodulation techniques have been proposed as a treatment for chronic stroke, acute stimulation is rarely studied due to concerns about exacerbating ischemia-induced electrical instability. Here, we demonstrate that acute cortical electrical stimulation, administered one hour post-stroke, provides neuroprotection in non-human primate brains. Using advanced electrophysiology and histology tools, we found that applying continuous theta burst electrical stimulati

SUBMITTER: Zhou J 

PROVIDER: S-EPMC12280128 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature