Probiotic-mediated modulation of gut microbiome in students exposed to academic stress: a randomized controlled trial.

ABSTRACT: Probiotics have been widely tested for their effect on mental well-being, albeit with heterogeneous outcomes. Direct and indirect effects through the gut microbiome might lie at the basis of these observations. Here, in a post-hoc analysis, we assessed the effect of 4-week consumption of a probiotic candidate strain on the gut microbiome in students exposed to academic stress. Healthy students were randomized to consume a fermented milk product with Lacticaseibacillus rhamnosus CNCM I-3690 (N = 39) or an acidified non-fermented milk product (N = 40) twice daily for 4 weeks before academic exams. The gut microbiome was analysed by Quantitative Microbiome Profiling based on 16S rRNA gene amplicon and shotgun metagenomic sequencing. Stress and anxiety were assessed using both objective and se

SUBMITTER: Vazquez-Castellanos JF 

PROVIDER: S-EPMC12280152 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature