Enhanced theta oscillations in the left temporoparietal region associated with refractory positive symptoms in schizophrenia.

ABSTRACT: Positive symptoms are a prominent feature of schizophrenia. Despite antipsychotic treatment, ~30% of patients develop refractory positive symptoms (RPSs). Current research fails to elucidate the potential neurophysiological mechanisms underlying RPSs, thereby hindering the development of additional treatments. This study, which included 37 patients with RPSs and 40 with non-refractory positive symptoms (NRPSs), aimed to explore their underlying neural mechanisms. Outcome measures were relative power spectrum density and interregional synchronization across frequency bands and theta-gamma phase-amplitude coupling (θ-γ PAC). The single-frequency analysis indicated that RPSs exhibited elevated theta power and reduced lateralization in the left temporal lobe and temporo-parietal junction, alon

SUBMITTER: Wang X 

PROVIDER: S-EPMC12280195 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature