Multi-omics profiling reveals distinct pathogenic mechanisms in Hunner and non-Hunner interstitial cystitis subtypes.

ABSTRACT: Bladder Pain Syndrome/Interstitial Cystitis encompasses Hunner lesion and non-Hunner lesion (NHIC) subtypes, characterized by chronic pelvic pain and urinary symptoms. The two subtypes show distinct clinical presentations, yet their underlying mechanisms remain poorly understood. Advancements in biological detection technologies allow for deeper insights into disease pathogenesis through integrated multi-omics approaches. This study aims to delineate the differences between NHIC and HIC using multi-omics analysis to uncover distinct microbiome, metabolome, and transcriptome profiles, thereby elucidating their unique pathogenic mechanisms. We conducted a comprehensive analysis involving bladder tissue samples and urine specimens from NHIC and HIC patients. Genomic, metabolomic, and transcri

SUBMITTER: Zhu L 

PROVIDER: S-EPMC12280205 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature