Functional Food Ge-Zhi Soup Ameliorates Acute Liver Injury Through the AKT/GSK3β/PPARα Pathway.

ABSTRACT: Ge-Zhi soup (GZS), mainly consisting of Puerariae lobata (Willd.) Ohwi and Hovenia acerba Lindl. seeds, is a traditional functional food widely consumed globally and has been proven to have considerable potential in preventing acute liver injury (ALI). However, its specific active ingredients and underlying mechanisms remain underexplored. In this study, the hepatoprotective effects, active ingredients, and underlying mechanisms of GZS were studied in ALI mice. We first determined the hepatoprotective effects of GZS and evaluated its function by analyzing biochemical parameters and histopathological changes in ALI mice. To elucidate the underlying mechanisms, an integrated strategy combining serum pharmacochemistry, network pharmacology, and non-targeted metabolomics was empl

SUBMITTER: Yao X 

PROVIDER: S-EPMC12280231 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature