Exploration of circulating metabolites in infants with abusive head trauma.

ABSTRACT: Abusive head trauma (AHT) is a severe form of traumatic brain injury (TBI) and causes significant brain lesions by vigorous shaking. It is the leading cause of mortality and morbidity in children under 2 years of age. If not fatal, AHT can result in severe disabilities, often requiring long-term care. Clinical diagnosis of AHT is challenging, because symptoms are often non-specific, overlap with those of other diseases and relies on screening for intracranial, spinal, and ocular lesions. To date, no screening test has been developed to preselect children suspected to be victims of AHT for further clinical investigations. However, as recently demonstrated via analysis of serum proteomes of infant victims of AHT, large-scale omic analysis of blood serum samples could help identify molecules

SUBMITTER: Maret E 

PROVIDER: S-EPMC12280348 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature