Clinical pharmacokinetics of potassium competitive acid blockers: a systematic review and meta-analysis.

ABSTRACT:

Background

Potassium competitive acid blockers (P-CABs) are a new class of acid suppressants that provide rapid and sustained inhibition of gastric acid secretion. Understanding the pharmacokinetic (PK) characteristics of P-CABs in various therapeutic uses is essential for optimizing treatment. This study aims to investigate the PK properties of P-CABs, focusing on drug interactions, food effects, and formulation impacts on their exposure and bioavailability.

Methods

We systematically searched MEDLINE and Embase up to July 2024. The search terms included "Potassium competitive acid blockers" or "P-CABs" or "revaprazan" or "vonoprazan" or "tegoprazan" or "fexuprazan" or "keverprazan" or "zastaprazan" and "pharmacokinetics".

Results

A total of 37 studies were included.

SUBMITTER: Liu J 

PROVIDER: S-EPMC12280725 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature