Peripheral Blood BRCA1 Methylation Positively Correlates with Major Alzheimer's Disease Risk Factors.

ABSTRACT:

Background

Recent biomarker studies demonstrated that the central nervous system (CNS) environment can be observed from peripherally-derived samples. In a previous study, we demonstrated significant hypomethylation of the BRCA1 promoter region in neuronal cells from post-mortem brains of Alzheimer's disease patients through neuron-specific methylome analysis. Thus, we investigate the methylation changes in the BRCA1 promoter region in the blood samples.

Objectives

To analyze the methylation level of the BRCA1 promoter in peripheral blood from AD patients and normal controls.

Design, setting, participants

Genomic DNA samples from peripheral blood were obtained from the J-ADNI repository, and their biomarker data were obtained J-ADNI from the National Bioscience Databas

SUBMITTER: Mano T 

PROVIDER: S-EPMC12280732 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature