Association of Subjective Cognitive Decline with Risk of Cognitive Impairment and Dementia: A Systematic Review and Meta-Analysis of Prospective Longitudinal Studies.

ABSTRACT:

Background

Subjective cognitive decline (SCD) as an early pathological manifestation of brain aging has become more prevalent among older adults.

Objectives

We aimed to investigate the associations of subjective cognitive decline (SCD) with the combined risk of cognitive impairment and dementia.

Design

We performed a systematic review and meta-analysis via searching Embase, PubMed and Cochrane electronic databases from January 1 st 1970 to June 4th, 2020.

Setting

Prospective cohort studies Participants: Healthy individuals were recruited from community, clinics and population.

Measurements

Healthy individuals with SCD were classified into exposure groups, while those without were considered as the reference group. Adjusted relative risks (RR) were estima

SUBMITTER: Wang XT 

PROVIDER: S-EPMC12280825 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature