EDNRB2 regulates fate, migration, and maturation of hair cell precursors in regenerating avian auditory epithelium explants.

ABSTRACT: The mammalian cochlea loses its ability to regenerate hair cells (HCs) after birth. In contrast, in the avian auditory epithelium, the basilar papilla (BP), supporting cells (SCs) retain the capability for HC regeneration throughout life. Our previous study using single-cell RNA sequencing indicated a stepwise fate conversion of SCs to HCs via a precursor state, in which endothelin receptor type B2 (EDNRB2) exhibited specifically high expression during HC regeneration in chick BP. This study aimed to reveal the distinct role of EDNRB2 in HC regeneration in the chick BP. During HC regeneration in chick BP explant cultures, EDNRB2 expression was observed in some ATOH1-expressing SCs immediately after HC loss and decreased as the HC regeneration process progressed.

SUBMITTER: Takeuchi M 

PROVIDER: S-EPMC12280915 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature