<i>Piezo2</i>+ mechanosensory neurons orchestrate postnatal development through mechano-chemo-transduction of PDGFA signaling.

ABSTRACT: Mechanical forces are ubiquitous and essential during vertebrate development, yet how these forces are translated into biochemical signals and regulate development during postnatal organogenesis remains poorly understood. While early embryogenesis relies on cell-autonomous mechanotransduction, the role of sensory innervation-abundant in postnatal stages-has been overlooked. Here, using the postnatal mouse molar development model, a system experiencing sustained mechanical forces and extensive innervation during tooth root formation, we first identify a subpopulation of Piezo2+ mechanosensory neurons in the trigeminal ganglia and reveal these neurons specifically detect tooth root-associated mechanical forces and orchestrate tooth root development via paracrine signaling. Critically,

SUBMITTER: Meng L 

PROVIDER: S-EPMC12280930 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature