Functional Dendrimer Nanogels for DNA Delivery and Gene Therapy of Tumors.

ABSTRACT: Solving the dilemma between efficacy and cytotoxicity of cationic colloidal vectors is one of the biggest challenges in gene delivery. Cationic dendrimer assemblies with hierarchical structure, smart and biomimetic behaviors have been developed for drug/gene delivery in vivo. Among different dendrimer assemblies, the dendrimer-based nanogels were not intensively studied due to complicated synthesis and unknown properties. Here, for the first time, low-generation dendrimer nanogels with high yield and purity, tunable size, uniform morphology, and good colloidal stability were synthesized using the emulsion-free method, which cannot be obtained by the miniemulsion method. Importantly, the dendrimer nanogels integrate the advantages of low-generation dendrimer and stimuli-responsive polymer,

SUBMITTER: Li X 

PROVIDER: S-EPMC12281078 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature