UPL3 promotes BZR1 degradation, growth arrest, and seedling survival under starvation stress in Arabidopsis.

ABSTRACT: Sugar-mediated regulation of hormone signaling is crucial for optimizing growth under normal conditions and ensuring survival during environmental stress. Previous studies have shown that sugar starvation induces the degradation of BRASSINAZOLE RESISTANT 1 (BZR1), the master transcription factor of the brassinosteroid (BR) signaling pathway, thereby inhibiting growth. However, the molecular mechanism linking sugar signaling to BZR1 degradation remains unknown. To identify proteins that mediate starvation-induced BZR1 degradation, we performed a quantitative proteomic analysis of the BZR1 interactome under starvation conditions and identified UBIQUITIN PROTEIN LIGASE 3 (UPL3) as a sugar-regulated protein that promotes BZR1 degradation and regulates growth and survival in response to sugar a

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12281193 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature