Omega‑3 Modify the Adverse Effects of Long-Term Exposure to Ambient Air Pollution on the Incidence of Chronic Obstructive Pulmonary Disease: Evidence from a Nationwide Prospective Cohort Study.

ABSTRACT: We aim to assess the modification effects of omega-3 polyunsaturated fatty acid (PUFA) levels on relationships between long-term air pollutants exposure and chronic obstructive pulmonary disease (COPD) risk. A total of 82,706 nonsmokers were finally included in the UK Biobank. The concentrations of circulating omega-3 PUFA (including total omega-3 and docosahexaenoic acid [DHA]) were measured by using a targeted high-throughput nuclear magnetic resonance metabolomics platform. Land-use regression models were used to estimate concentrations of nitrogen dioxide (NO₂) and particulate matter (PM_2.5 and PM₁₀) for each individual. Additionally, systemic inflammation levels were assessed using the low-grade inflammation score (INFLA-score) to elucidate the potenti

SUBMITTER: Ma J 

PROVIDER: S-EPMC12281204 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature