Serial Cross-Sectional Human Biomonitoring Analysis of Pesticide Exposure Patterns and Their Association with Lipid Metabolism Biomarkers: The Mediating Role of Liver Function.

ABSTRACT: Continuous low-level exposure to pesticides is inevitable in daily life. Previous studies have demonstrated the adverse effects of pesticide exposure on lipid metabolism. However, population studies have focused primarily on individual pesticides and have short-term fluctuations, and the animal experiments used doses far higher than those exposed by the general population. In this study, urinary concentrations of metabolites of three classes of pesticides, including organophosphate, pyrethroid, and phenoxy carboxylic acid, were determined in 1858 participants of repeated cross-sectional biomonitoring programs from 2018 to 2022. We comprehensively analyzed the association of pesticide metabolites and pesticide exposure patterns with lipid metabolism biomarkers. The indirect effects of liver

SUBMITTER: Jia X 

PROVIDER: S-EPMC12281205 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature