The Impact of Genetic Variation on Drug Response in Adult IBD: A Systematic Review.

ABSTRACT:

Background

A major characterization of inflammatory bowel disease (IBD) is significant heterogeneity in treatment responses. Despite the increase in therapeutic agents, discovering an optimal patient-level treatment is still a major milestone. This study aims to provide a systematic review of the existing literature on the predictive biomarkers of the response to IBD treatment.

Methods

On April 15, 2025, a literature search was conducted using the PubMed and Scopus databases, as well as a manual search. Controlled trials, case-control studies, cross-sectional studies, and cohort studies addressing predictive biomarkers for treatment response in adults with IBD were eligible for inclusion. The CASP tool was used to assess the quality of the methodologies employed in the inclu

SUBMITTER: Askari M 

PROVIDER: S-EPMC12281211 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature