Porcine Fetal Hypothyroidism Induces Temporal and Tissue-Specific Alterations in the Insulin-Like Growth Factor System.

ABSTRACT: To characterize the interaction between the fetal thyroid and IGF system, we utilized a temporal model of porcine fetal hypothyroidism. N = 24 pregnant gilts were split into two treatment groups, with 12 gilts receiving a daily oral dose of 5 mg/kg methimazole (MMI) to induce fetal hypothyroidism, and 12 gilts serving as a control. Within each group, three gilts began treatment at gestational Days 34, 45, 55, or 65 of gestation, with gilts euthanized 21 days later to allow for fetal sample collection. Fetuses from the MMI groups were confirmed hypothyroid by the presence of goiter, as well as reduced circulating thyroxine levels at all four timepoints, and reduced circulating triiodothyronine levels at the two later timepoints. Samples of fetal liver and kidney were taken from four fetuses

SUBMITTER: Smith AA 

PROVIDER: S-EPMC12281263 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature