Spontaneous peripheral artery rupture in patients with neurofibromatosis type 1.

ABSTRACT: Artery rupture is a very rare but severe complication of neurofibromatosis type 1 (NF1), an autosomal-dominant genetic disorder, and the optimal treatment is not yet clear. We present two cases who presented with different types of artery rupture related to NF1 at our center within a short period and review similar cases reported previously to discuss the suitable therapy for this complication. We concluded that an NF1 gene mutation affects the structure of the artery, makes the artery fragile, thick, and prone to rupture, and endovascular treatment should be considered as the first choice.

SUBMITTER: Che L 

PROVIDER: S-EPMC12281292 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature