A map of integrated cis-regulatory elements enhances gene-regulatory analysis in maize.

ABSTRACT: cis-regulatory elements (CREs) are non-coding DNA sequences that modulate gene expression. Their identification is essential to the study of transcriptional regulation of genes that control key traits involved in plant growth and development. CREs are also critical for the delineation of gene-regulatory networks (GRNs), which map regulatory interactions between transcription factors (TFs) and target genes. In maize, CREs have been profiled using various computational and experimental methods, but the extent to which these approaches complement each other when identifying functional CREs remains unclear. Here, we report the data-driven integration of multiple maize CRE-profiling methods to optimize the capture of experimentally confirmed TF-binding sites, resulting in a map of integrated CR

SUBMITTER: Staut J 

PROVIDER: S-EPMC12281299 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature