Preoptic area influences sleep-related seizures in a genetic epilepsy mouse model.

ABSTRACT: In patients with refractory epilepsy, states of sleep and wakefulness affect the expression of seizures. However, the mechanism by which subcortical sleep circuitry affects seizures is unknown. Here, using Gabrg2Q390X knock-in (KI) genetic epileptic mouse model, we found that during sleep, subcortical preoptic area (POA) neurons were active in het Gabrg2Q390X KI mice and their activity preceded or/and coincided with epileptic (poly)spike-wave discharges. Optogenetic manipulating the POA activity altered sleep/wake periods in wild-type (wt) and the het Gabrg2Q390X KI mice. Most importantly, short-period optogenetic activation of epileptic cortical neurons alone did not effectively trigger seizures in the het Gabrg2Q390X KI mice, while optogenetic activation of the POA nucleus slightly influ

SUBMITTER: Potesta CV 

PROVIDER: S-EPMC12281508 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature