Type 1 interferon signalling orchestrated by gut microbiota suppresses IgE-mediated anaphylaxis associated with vitamin D3 signalling.

ABSTRACT:

Objective

IgE/antigen (Ag)-mediated systemic anaphylaxis (SA) involves alterations in type 1 interferon (IFN1), vitamin D3(VD3) and the gut microbiota. However, their interactions remain largely unknown. This study aimed to investigate the interactions between IFN1 and VD3 signalling at steady-state and their relationships with the gut microbiota underlying SA.

Methods

Female adult C57BL/6 mice lacking IFN1 alpha receptor subunit 1 (Ifnar1, Ifnar1 ^-/-), immune-related GTPase family M protein 1 (Irgm1, Irgm1 ^-/-) or VD3 receptor (Vdr, Vdr ^-/-) were intravenously (IV) administered with IgE/Ag to induce passive SA (PSA) or intraperitoneally (IP) administered ovalbumin (OVA) on days 1, 15, and 29, followe

SUBMITTER: Chen B 

PROVIDER: S-EPMC12281519 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature