A reagent-free, fouling-resistant electrochemical multifunctional peptide sensor for highly sensitive and rapid detection of Alzheimer's disease biomarkers.

ABSTRACT: β-amyloid (Aβ) aggregates are critical biomarkers for the early diagnosis of Alzheimer's disease (AD). Numerous studies have shown that blood-based detection of Aβ aggregates can achieve similar or higher diagnostic accuracy than clinical cerebrospinal fluid tests. In this study, a reagent-free, anti-fouling electrochemical sensor based on a peptide aptamer was developed. This sensor exhibited anti-fouling and specific recognition capabilities, enabling highly sensitive and selective quantitative detection of Aβ aggregates in blood. The multifunctional peptide (MF-peptide) incorporated a hydrophilic sequence of alternating lysine (K) and glutamic acid (E) residues into the Aβ recognition peptide. The MF-peptide sensor was fabricated via the self-assembly of the MF-peptide onto a working el

SUBMITTER: Ji Y 

PROVIDER: S-EPMC12281522 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature