Janus Ag/Fe-HfO₂ nanoparticles for enhanced radio-photothermal tumor therapy via magnetic resonance imaging and multienzyme activity.

ABSTRACT: A significant challenge in modern radiotherapy (RT) is to minimize the detrimental effects on adjacent healthy tissues while concurrently increasing the susceptibility of tumor tissue to radiation. Investigating nanoradiosensitizers with multifunctional properties has a lot of potential as a highly effective strategy for augmenting the efficacy of RT. A novel Janus Ag/Fe-HfO₂ nanoparticle was synthesized in a single-step process. This versatile nanoradiosensitizer combines photothermal capabilities, enzyme-like activities, and the capacity for magnetic resonance imaging (MRI). The surfaces have been meticulously engineered with PEG to boost biocompatibility and adorned with RGD-targeting peptides that selectively target tumor cells (Ag/Fe-HfO₂-PEG-RGD). The characteri

SUBMITTER: Liu X 

PROVIDER: S-EPMC12281546 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature