A bio-inspired screwed small-diameter vascular graft for endotheliazation and arterial regeneration.

ABSTRACT: The frequent failures of small-diameter vascular grafts (SDVGs) mainly result from thrombosis and insufficient endothelialization. Despite recent biochemical modification strategies aiming to enhance long-term patency, the challenges of suppressing thrombosis and promoting rapid endothelialization persist. We thus designed a biomimetic three-layer flexible vascular graft scaffold. This scaffold precisely replicates the nonlinear mechanical responses of vascular tissues and promotes vascular regeneration by minimizing the mechanical mismatch between the graft and the host. The biomimetic flexible SDVG scaffold comprises a screwed inner layer, a middle fabric layer, and a Polyethylene terephthalate (PET) helical coil. It shows excellent bending resistance and resilience, reducing thrombosis

SUBMITTER: Huang Q 

PROVIDER: S-EPMC12281551 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature