Hypertension promotes neuroinflammation, brain injury and cognitive impairment.

ABSTRACT:

Background

Hypertension increases the risk for cognitive impairment and promotes vascular and renal inflammation. We tested if immune cell infiltration occurs in the brain during hypertension and if it is associated with cognitive impairment.

Methods

Male C57Bl/6 mice were administered vehicle, angiotensin II (0.7 mg/kg/d S.C.) or aldosterone (0.72 mg/kg/d S.C.) via osmotic minipumps. A subset of mice also received hydralazine (50 mg/kg) in their drinking water after minipump implantation. We measured systolic blood pressure, markers of inflammation, working memory and transcriptomic changes in the brain.

Results

Administration of angiotensin II or aldosterone increased blood pressure and promoted blood-brain barrier dysfunction, leukocyte accumulation and impairment

SUBMITTER: Dinh QN 

PROVIDER: S-EPMC12281552 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature