Synthesis of 2-Azaanthraquinones from 1,4-Oxazinone Precursors.

ABSTRACT: The synthesis of 2-azaanthraquinone structures from 1,4-oxazinone precursors is described. A new method for the synthesis of 1,4-oxazinones is also reported. The key discovery is the reaction of oxazinone and quinone starting materials through a tandem cycloaddition/cycloreversion sequence and in situ oxidation to deliver azaquinone products. Insights into the reactivity and selectivity of oxazinone precursors, as well as the description of new biologically active 2-azaanthraquinones further supplement this study.

SUBMITTER: Thompson LC 

PROVIDER: S-EPMC12281559 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature