Development of a Diastereoselective Csp²-Csp³ Cross-Coupling Reaction Inspired by Macrocyclic RiPP Natural Products.

ABSTRACT: Macrocyclic peptides containing C(sp²)-C(sp³) side chain cross-links are a rapidly growing subclass of ribosomally synthesized and post-translationally modified peptides (RiPPs), with significant potential in the development of new pharmaceuticals. This report presents a method for the efficient synthesis of derivatives of this class using a diastereoselective cross-electrophile coupling for the formation of the key β-aryl-alkyl cross-link.

SUBMITTER: Plouch EV 

PROVIDER: S-EPMC12281569 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature