Anticancer effects and mechanisms of <i>Pulsatilla chinensis</i>, <i>Bupleurum chinense</i> and <i>Polyporus umbellatus</i> on human lung carcinoma and hepatoma cells.

ABSTRACT: Herbs are extensively utilized in Traditional Chinese Medicine (TCM) for lung and liver cancer treatment, but the mechanisms behind these herbs remain largely unknown. Here, high-throughput transcriptomic analysis technology was used to uncover molecular mechanisms of herbal treatment. Furthermore, we developed a compound recognition approach utilizing the LINCS L1000 database to identify potential treatment targets. Our results showed that among 14 herbs tested, Pulsatilla chinensis exhibited the strongest anticancer effects in A549 and Huh7 cells, followed by Bupleurum chinense, and Polyporus umbellatus. P. chinensis exerts its anticancer properties by downregulating cell cycle-related transcription factors, including E2F1 and TFDP1. Notably, the mechanisms of

SUBMITTER: Li M 

PROVIDER: S-EPMC12281591 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature