Investigating the Potential of Division of Labor in Synthetic Bacterial Communities for the Production of Violacein.

ABSTRACT: With advancements in synthetic biology and metabolic engineering, microorganisms can now be engineered to perform increasingly complex functions, which may be limited by the resources available in individual cells. Introducing heterologous metabolic pathways introduces both genetic burden due to the competition for cellular transcription and translational machinery, as well as metabolic burden due to the redirection of metabolic flux from the native metabolic pathways. Division of labor in synthetic microbial communities offers a promising approach to enhance metabolic efficiency and resilience in bioproduction. By distributing complex metabolic pathways across multiple subpopulations, the resource competition and metabolic burden imposed on an individual cell are reduced, potentially enab

SUBMITTER: Mehta H 

PROVIDER: S-EPMC12281613 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature