The value of habitat analysis based on ¹⁸F-PSMA-1007 PET/CT images for prostate cancer risk grading.

ABSTRACT:

Purpose

To evaluate the performance of habitat analysis by positron emission tomography (PET)/computed tomography (CT) with ¹⁸F-prostate-specific membrane antigen (PSMA)-1007 (¹⁸F-PSMA-1007 PET/CT) for prediction of risk grading based on the Gleason Score (GS) for primary prostate cancer (PCa).

Methods

The data of 42 PCa patients who underwent ¹⁸F-PSMA-1007 PET/CT before puncture biopsy or radical prostatectomy were included for analysis. The whole prostate was manually contoured on PET and CT images as the volume of interest (VOI). Using the Otsu algorithm, the VOI was divided into four habitat subregions. Independent risk factors were screened and a combined model was constructed to predict GS grade by univariate logistic regression followe

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12281703 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature