A lethal DENV-2 wild-type mouse model for mutagenesis investigations.

ABSTRACT:

Background

Effective mouse models for testing antiviral medications should be both cost-effective and require minimal labor. Immunodeficient mouse models, such as AG129, are commonly used in dengue virus (DENV) research; however, their high import and maintenance costs make them relatively expensive. Moreover, the absence of IFN-γ signaling limits the capacity of the AG129 model. To date, wild-type mouse models of DENV infection have only exhibited mild symptoms without lethality, limiting their research applicability. In this study, we developed a lethal C57BL/6 wild-type mouse model infected with DENV-2 365 strain. By blocking the type I interferon receptor before the virus challenge, we allowed the immune response to be restored at a later stage of infection.

Results

Foll

SUBMITTER: Qin Z 

PROVIDER: S-EPMC12281760 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature