Programmed cell death regulates hematopoietic cell homeostasis under radiation conditions.

ABSTRACT:

Background

It is well-known that hematopoietic cells are sensitive to irradiation exposure. Apoptosis, necroptosis, pyroptosis and ferroptosis might contribute to irradiation-induced hematopoietic injury. However, it is uncertain whether different hematopoietic cells apply specific cell death pathways under irradiation exposure.

Methods

We investigated the role of different programmed cell death pathways in irradiation-induced hematopoietic cell injury. In order to study the acute and long-term effects of ionizing radiation on hematopoietic system, we established injury models of mice at different time points after irradiation and measured the proportion of hematopoietic stem progenitor cells by flow cytometry. The pattern of programmed cell death involved in radiation-induc

SUBMITTER: Shu M 

PROVIDER: S-EPMC12281764 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature