Untargeted metabolomics-based elucidation of metabolic reprogramming mechanisms and pathways following aortic dissection surgery.

ABSTRACT:

Background

Postoperative complications persist in acute DeBakey type I aortic dissection (AD) despite surgical advances, yet the underlying metabolic mechanisms remain unexplored. This knowledge gap critically limits targeted interventions.

Methods

Untargeted metabolomics using ultra-high-performance liquid chromatography-mass spectrometry (UHPLC-MS) was performed on 90 serum samples, including: preoperative AD patients (n = 30), postoperative samples from the same cohort (AT group, n = 30), and healthy controls (HC, n = 30). Multivariate statistics through orthogonal partial least squares-discriminant analysis (OPLS-DA) identified differential metabolites (variable importance in projection [VIP] > 1, P < 0.05), with Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment

SUBMITTER: He J 

PROVIDER: S-EPMC12281785 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature