Metal-organic nanostructures based on sono/chemo-nanodynamic synergy of Ti<sub>x</sub>O<sub>y</sub>/Ru reaction units: for ultrasound-induced dynamic cancer therapy.
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ABSTRACT: Sonodynamic therapy (SDT) exhibits clinical potential for deep-tissue tumor treatment due to its deep tissue penetration and spatiotemporal controllability. Its core mechanism relies on ultrasound-activated sonosensitizers to generate reactive oxygen species (ROS), thereby inducing tumor cell apoptosis. However, conventional sonosensitizers face limitations in ROS yield and tumor-targeting efficiency. In this study, we innovatively designed a multifunctional metal-organic nanosheet (TiZrRu-MON) by hydrothermal coordination of [Ru(bpy)₃]2⁺ photosensitizing units with TiZr-O clusters, while incorporating Fe3⁺ to construct a cascade catalytic system. Experimental results demonstrated that: (1) Fe3⁺ lattice doping significantly enhanced charge carrier mobility
SUBMITTER: Jiang T
PROVIDER: S-EPMC12281788 | biostudies-literature | 2025 Jul
REPOSITORIES: biostudies-literature
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