The prognostic significance and Immunomodulatory role of SCGB3A1 expression in stage I lung adenocarcinoma.

ABSTRACT:

Background

Many early-stage lung adenocarcinoma patients experience recurrence or metastasis after surgery, and the efficacy of targeted therapies remains suboptimal, significantly impacting the prognosis of these patients. Our study aims to investigate the impact of SCGB3A1 on the prognosis of lung adenocarcinoma patients and its role in immunity. We propose that SCGB3A1 may offer a novel treatment approach for lung adenocarcinoma patients who do not respond well to targeted therapies.

Methods

We obtained RNA sequencing data from 539 lung adenocarcinoma samples, 59 normal tissues, and 2 metastatic cancer tissues from The Cancer Genome Atlas database. Using Venn diagrams, we analyzed the expression of SCGB3A1 and other differentially expressed genes (DEGs) in different patie

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12281796 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature