Wide-scale geographical analysis of genetic ancestry in the South African Coloured population.

ABSTRACT:

Background

The South African Coloured (SAC) population, a prominent admixed population in South Africa, reflects centuries of migration, admixture, and historical segregation. Descendants of local Khoe-San and Bantu-speaking populations, European settlers, and enslaved individuals from Africa and Asia, SAC individuals embody diverse ancestries. This study investigates the genetic makeup of SAC individuals, utilizing autosomal genotypes, mitochondrial DNA and Y-chromosome data. We analyse new genotype data for 125 SAC individuals from seven locations.

Results

Our analysis, based on a dataset comprising 356 SAC individuals from 22 geographic locations, revealed significant regional variations in ancestry. Khoe-San ancestry predominates in 14 locations, highlighting its lasting

SUBMITTER: Lankheet I 

PROVIDER: S-EPMC12281806 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature