Gammaherpesvirus infection unveils exaggerated germinal center responses in an SR-BI-deficient host.

ABSTRACT: Lipid metabolism has emerged as an important regulator of acute viral infections by affecting viral replication and the host immune response. In contrast, the role of host lipid metabolism during chronic viral infection has been less explored. The current study aims to define the role of scavenger receptor class B type I (SR-BI), a primary physiologic receptor for high-density lipoprotein (HDL), during natural gammaherpesvirus infection. Gammaherpesviruses are highly prevalent cancer-associated pathogens that induce and manipulate germinal center responses to establish life-long infection of B cells. Importantly, gammaherpesvirus-infected germinal center B cells are thought to be the target of viral transformation. In this study, we found that global SR-BI deficiency led to increased gamma

SUBMITTER: Schmalzriedt DL 

PROVIDER: S-EPMC12282102 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature