Virocell resource manipulation under nutrient limitation.

ABSTRACT: Virus-infected cells, called virocells, impact host metabolic functions, resources, and ecosystem processes, but the effects of nutrient limitation remain less well understood. Here, we leverage transcriptomic, proteomic, and endo- and exo-metabolomic data from two Pseudoalteromonas virocells independently infected by unrelated dsDNA viruses, PSA-HS2 (HS2-virocells) and PSA-HP1 (HP1-virocells), to examine how phosphate limitation affects virocell resource manipulation intra- and extracellularly. Intracellularly, we find that (i) HP1-virocells boost amino acid production toward the end of the infection cycle but deplete amino acid pools relative to HS2-virocells; (ii) both virocells dampen the production of de novo nucleotide synthesis proteins; (iii) HS2-virocells switch from

SUBMITTER: Lindback MM 

PROVIDER: S-EPMC12282109 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature