ATG5 negatively regulates grass carp reovirus-induced immune-inflammatory response by degrading RIG-I and MDA5.

ABSTRACT: Grass carp reovirus (GCRV) is the most virulent aquareovirus, inducing hemorrhagic disease that results in significant economic losses for the grass carp aquaculture industry in China. It has been reported that the cytokine storm, resulting from the viral-induced acute immune-inflammatory response, is the primary cause of death associated with viral infections. Therefore, exploring the negative regulatory factors of the immune response may provide important targets for virus prevention and control. In this study, we demonstrated that GCRV infection induces an acute immune-inflammatory response in yearling grass carp, while a milder immune response is observed in 3-year-old grass carp by assessing key gene expression at both the mRNA and protein levels. Furthermore, we found that the upregu

SUBMITTER: Chu P 

PROVIDER: S-EPMC12282135 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature