Regulatory networks of FUR and NtcA are intertwined by transcriptional regulators, two-component systems, serine/threonine kinases, and sigma factors in <i>Anabaena</i> sp. PCC 7120.

ABSTRACT: FUR proteins in Anabaena sp. PCC 7120 (FurA/Fur, FurB/Zur, and FurC/PerR) are a family of transcriptional regulators involved in the control of highly important metabolic processes such as the maintenance of metal homeostasis, the regulation of oxidative stress response, and the adaptation to nitrogen starvation. Previous RNAseq analyses of FUR misregulation strains revealed a broad panel of genes directly modulated by these transcriptional regulators. However, the expression of several regulatory proteins was also altered, indicating that FUR proteins could extend their influence by exerting a second level of regulation through some members of their regulons. In this work, by combining differential gene expression data and electrophoretic mobility shift assays (EMSAs), we sought to

SUBMITTER: Guio J 

PROVIDER: S-EPMC12282138 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature