Enterovirus C recombination groups: RNA sequence similarity and the viral polymerase underpin sexual replication mechanisms.

ABSTRACT: Enteroviruses frequently recombine with one another in nature; however, it is unclear how viral replication machinery can distinguish between related and unrelated partners during recombination. We hypothesize that viral RNA recombination involves two parental RNA templates, nascent RNA products, and their dynamic interactions with the viral polymerase-a sexual replication strategy. When nascent RNA products move from one parental RNA template to another, RNA sequence similarity may be an important factor underpinning the mechanism and efficiency of recombination. To test this hypothesis, we focused on recombination between two related group C enteroviruses, poliovirus and Coxsackievirus A21 (CVA21), using bioinformatic, biological, and biochemical approaches. Bioinformatic analyses compar

SUBMITTER: Okolovitch EM 

PROVIDER: S-EPMC12282145 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature