<i>Bordetella pertussis</i> exhibits genomic diversity within patients and laboratory culture.

ABSTRACT: Over the past decade, genomic characterization of Bordetella pertussis isolates recovered from US pertussis patients has unveiled noteworthy structural gene order variations. Whole-genome sequencing (WGS) shows that although B. pertussis exhibits little gene sequence variation, genomes from clinical isolates frequently differ in gene order through rearrangement between insertion sequence elements. To better understand rates of genome rearrangement and single nucleotide polymorphism (SNP) in B. pertussis, intra-patient genomic diversity was examined. Five states submitted, on average, five isolates per patient specimen following culture confirmation to the US Centers for Disease Control and Prevention for molecular characterization. Analysis of 149 patient specimen sets

SUBMITTER: Bouda E 

PROVIDER: S-EPMC12282162 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature