Phosphoglucomutase A-mediated metabolic adaptation is essential for antibiotic and disease persistence in <i>Mycobacterium tuberculosis</i>.

ABSTRACT: The long-term survival of Mycobacterium tuberculosis (Mtb) requires efficient use of host resources and uninterrupted access to host-derived nutrients. This is done by utilization of a highly flexible and integrated network of metabolic pathways. Phosphoglucomutase A (pgmA) is essential for glycogen biosynthesis, which acts as a nutrient reservoir and is known to modulate carbon flux in various pathogens. We, for the first time, investigated the role of pgmA in Mtb by creating a strain lacking this gene. The absence of pgmA hinders the survival of pathogens under nutrient-limiting and reactivation conditions. Our study shows that the lack of cell membrane-associated glycolipids in ΔpgmA compromises cell wall integrity and increases susceptibility to stres

SUBMITTER: Sharma T 

PROVIDER: S-EPMC12282177 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature